{"id":468,"date":"2025-08-15T06:55:05","date_gmt":"2025-08-15T06:55:05","guid":{"rendered":"https:\/\/lwfzyzmd.com\/product\/%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc-%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc%e6%98%af%e4%b8%80%e6%ac%be%e9%92%88%e5%af%b9ntrk%e5%92%8cros1%e5%9f%ba%e5%9b%a0%e8%9e%8d%e5%90%88%e8%80%8c%e8%ae%be%e8%ae%a1\/"},"modified":"2026-09-23T00:38:10","modified_gmt":"2026-09-22T17:38:10","slug":"%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc-%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc%e6%98%af%e4%b8%80%e6%ac%be%e9%92%88%e5%af%b9ntrk%e5%92%8cros1%e5%9f%ba%e5%9b%a0%e8%9e%8d%e5%90%88%e8%80%8c%e8%ae%be%e8%ae%a1","status":"publish","type":"product","link":"https:\/\/laopharmacy.la\/th\/product\/%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc-%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc%e6%98%af%e4%b8%80%e6%ac%be%e9%92%88%e5%af%b9ntrk%e5%92%8cros1%e5%9f%ba%e5%9b%a0%e8%9e%8d%e5%90%88%e8%80%8c%e8%ae%be%e8%ae%a1\/","title":{"rendered":"Lucius LuciEntre Entrectinib 100mg (\u6069\u66f2\u66ff\u5c3c)"},"content":{"rendered":"

\u6069\u66f2\u66ff\u5c3c<\/strong>\u8bf4\u660e\u4e66<\/strong><\/p>\n

\u5546\u54c1\u540d\u79f0\uff1aLuciEntre<\/p>\n

\u751f\u4ea7\u5546\uff1a\u5362\u4fee\u65af\u5236\u836f\u00a0Lucius<\/p>\n

\u4e2d\u6587\u540d\u79f0\uff1a\u6069\u66f2\u66ff\u5c3c<\/p>\n

\u82f1\u6587\u540d\u79f0\uff1a\u00a0Entrectinib<\/p>\n

\u836f\u54c1\u6279\u51c6\u6587\u53f7\uff1a03\u00a0L 1075\/24<\/p>\n

 <\/p>\n

 <\/p>\n

\u3010\u6982\u62ec\u3011<\/strong><\/p>\n

\u6069\u66f2\u66ff\u5c3c\u662f\u4e00\u6b3e\u9488\u5bf9NTRK\u548cROS1\u57fa\u56e0\u878d\u5408\u800c\u8bbe\u8ba1\u7684\u7279\u5f02\u6027\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597NTRK\u878d\u5408\u9633\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u3002<\/p>\n

 <\/p>\n

\u3010\u9002\u5e94\u75c7\u3011<\/strong><\/p>\n

1\u3001\u60a3\u6709\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6210\u5e74\u60a3\u8005\uff0c\u5176\u80bf\u7624\u4e3aROS1-\u9633\u6027\u3002
\n2\u300112\u5c81\u53ca\u4ee5\u4e0a\u60a3\u6709\u5b9e\u4f53\u7624\u7684\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\uff0c\u8be5\u60a3\u8005\uff1a
\n\u2460\u5177\u6709\u795e\u7ecf\u8425\u517b\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176\uff08NTRK\uff09\u57fa\u56e0\u878d\u5408\u800c\u6ca1\u6709\u5df2\u77e5\u7684\u83b7\u5f97\u6027\u6297\u6027\u7a81\u53d8\uff1b
\n\u2461\u8f6c\u79fb\u6027\u6216\u624b\u672f\u5207\u9664\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u5e76\u53d1\u75c7\uff1b
\n\u2462\u5728\u6cbb\u7597\u540e\u6709\u8fdb\u5c55\u6216\u6ca1\u6709\u4ee4\u4eba\u6ee1\u610f\u7684\u66ff\u4ee3\u7597\u6cd5\u3002<\/p>\n

 <\/p>\n

\u3010\u89c4\u683c\u3011\u00a0\u00a0<\/strong><\/p>\n

100mg\/\u7c92\uff0c60\u7c92\/\u74f6<\/p>\n

 <\/p>\n

\u3010\u8d2e\u5b58\u3011<\/strong><\/p>\n

\u572820\u00b0C\u81f325\u00b0C\u7684\u5e72\u71e5\u5904\u4fdd\u5b58\u3002\u77ed\u9014\u5916\u51fa\u6e29\u5ea6\u5141\u8bb8\u81f315\u201330\u00b0C(59\u201386\u00b0F)\u3002<\/p>\n

\u00a0<\/strong><\/p>\n

\u3010\u00a0\u7528\u6cd5\u7528\u91cf\u3011<\/strong><\/p>\n

1\u3001ROS1-\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u63a8\u8350\u5242\u91cf\uff1a\u6bcf\u6b21\u53e3\u670d600 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u3002
\n2\u3001NTRK\u57fa\u56e0\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624\u7684\u63a8\u8350\u5242\u91cf\uff1a
\n\u2460\u6210\u4eba\uff1a\u6bcf\u6b21\u53e3\u670d600 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff1b
\n\u246112\u5c81\u53ca\u4ee5\u4e0a\u7684\u513f\u7ae5\u60a3\u8005\uff1a\u63a8\u8350\u5242\u91cf\u57fa\u4e8e\u4f53\u8868\u9762\u79ef\uff08BSA\uff09\uff0c\u5982\u4e0b\u6240\u793a\uff1a
\n\u2022BSA\u5927\u4e8e1.50 \u33a1\uff1a\u6bcf\u6b21\u53e3\u670d600 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff1b
\n\u2022BSA1.11\u81f31.50 \u33a1\uff1a\u6bcf\u6b21\u53e3\u670d500 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff1b
\n\u2022BSA0.91\u81f31.10 \u33a1\uff1a\u6bcf\u6b21\u53e3\u670d400 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u3002<\/p>\n

 <\/p>\n

\u3010\u00a0\u4e0d\u826f\u53cd\u5e94\u3011<\/strong><\/p>\n

1\u3001\u5e38\u89c1\uff1a<\/p>\n

1\uff09\u8179\u90e8\u6216\u80c3\u75db\u6216\u538b\u75db\u3001\u89c6\u529b\u6a21\u7cca\u3001\u707c\u70ed\u3001\u8815\u52a8\u611f\u3002<\/p>\n

2\uff09\u7619\u75d2\u3001\u9ebb\u6728\u3001\u523a\u75db\u3001\u201c\u9488\u624e\u201d\u6216\u523a\u75db\u611f\u3001\u8272\u89c9\u53d8\u5316\u3002<\/p>\n

3\uff09\u9676\u571f\u8272\u4fbf\u3001\u610f\u8bc6\u6a21\u7cca\u3001\u5c3f\u8272\u6697\u3001\u98df\u6b32\u4e0b\u964d\u3001\uff08\u667a\u529b\u3001\u77ed\u65f6\u8bb0\u5fc6\u3001\u5b66\u4e60\u80fd\u529b\u548c\u6ce8\u610f\u529b\uff09\u7f3a\u9677\u3002<\/p>\n

4\uff09\u591c\u95f4\u89c6\u529b\u56f0\u96be\u3001\u5934\u6655\u3001\u53d1\u70e7\u3001\u5934\u75db\u3001\u773c\u775b\u5bf9\u9633\u5149\u7684\u654f\u611f\u6027\u589e\u52a0\u3002<\/p>\n

5\uff09\u76ae\u75b9\u3001\u5173\u8282\uff08\u75bc\u75db\u3001\u50f5\u786c\u6216\u80bf\u80c0\uff09\u3001\u98df\u6b32\u4e0d\u632f\u3001\u8170\u75db\u3001\u4fa7\u75db\u3002<\/p>\n

6\uff09\u6076\u5fc3\u5455\u5410\u3001\u5e73\u8861\u95ee\u9898\u3001\u56f0\u5026\u6216\u5f02\u5e38\u56f0\u5026\u3001\u811a\u6216\u5c0f\u817f\u80bf\u80c0\u3002<\/p>\n

7\uff09\u7761\u7720\u56f0\u96be\u3001\u5f02\u5e38\u75b2\u5026\u6216\u865a\u5f31\u3001\u773c\u775b\u6216\u76ae\u80a4\u6cdb\u9ec4\u3002<\/p>\n

2\u3001\u4e0d\u5e38\u89c1\uff1a<\/p>\n

1\uff09\u80f8\u75db\u3001\u5c3f\u91cf\u51cf\u5c11\u3001\u9888\u9759\u8109\u6269\u5f20\u3001\u590d\u89c6\u3002<\/p>\n

2\uff09\u6781\u5ea6\u75b2\u52b3\u3001\u660f\u53a5\u3001\u547c\u5438\u4e0d\u89c4\u5219\u3001\u4e0d\u89c4\u5219\u5fc3\u8df3\u590d\u53d1\u3002<\/p>\n

3\uff09\u5931\u5fc6\u3001\u8bb0\u5fc6\u529b\u95ee\u9898\u3001\u8bf4\u8bdd\u95ee\u9898\u3001\uff08\u770b\u5230\u3001\u542c\u5230\u6216\u611f\u89c9\u5230\u4e0d\u5b58\u5728\u7684\u4e1c\u897f\uff09\u3001\uff08\u9762\u90e8\u3001\u624b\u6307\u3001\u811a\u6216\u5c0f\u817f\uff09\u80bf\u80c0\u3002<\/p>\n

4\uff09\u80f8\u95f7\u3001\u8bb0\u5fc6\u56f0\u96be\u3001\u547c\u5438\u56f0\u96be\u3001\u4f53\u91cd\u589e\u52a0\u3002<\/p>\n

\u00a0<\/strong><\/p>\n

\u3010<\/strong>\u6ce8\u610f\u4e8b\u9879<\/strong>\u3011<\/strong><\/p>\n

1\u3001\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff1a\u5728\u63a5\u53d7\u6069\u66f2\u66ff\u5c3c\u4e34\u5e8a\u8bd5\u9a8c\u7684355\u540d\u60a3\u8005\u4e2d\uff0c\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff08CHF\uff09\u53d1\u751f\u7387\u4e3a3.4%\uff0c\u5305\u62ec3\u7ea7\uff082.3%\uff09\u3002<\/p>\n

2\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6548\u5e94\uff1a\u63a5\u53d7\u6069\u66f2\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u5e7f\u6cdb\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8ba4\u77e5\u969c\u788d\u3001\u60c5\u7eea\u969c\u788d\u3001\u5934\u6655\u548c\u7761\u7720\u969c\u788d\u3002<\/p>\n

3\u3001\u9aa8\u6298\uff1a\u6069\u66f2\u66ff\u5c3c\u589e\u52a0\u4e86\u9aa8\u6298\u7684\u98ce\u9669\u3002\u5728\u4e00\u4e2a\u6269\u5927\u7684\u5b89\u5168\u6027\u8bd5\u9a8c\u4e2d\uff0c338\u540d\u6210\u4eba\u60a3\u8005\u548c30\u540d\u513f\u7ae5\u60a3\u8005\u63a5\u53d7\u6069\u66f2\u66ff\u5c3c\u6cbb\u7597\uff0c5%\u7684\u6210\u4eba\u60a3\u8005\u548c23%\u7684\u513f\u7ae5\u60a3\u8005\u53d1\u751f\u9aa8\u6298\u3002<\/p>\n

4\u3001\u809d\u6bd2\u6027\uff1a\u5728\u63a5\u53d7\u6069\u66f2\u66ff\u5c3c\u6cbb\u7597\u7684355\u4f8b\u60a3\u8005\u4e2d\uff0c42%\u7684\u60a3\u8005\u51fa\u73b0\u4e0d\u540c\u7ea7\u522b\u7684AST\u5347\u9ad8\uff0c36%\u7684\u60a3\u8005\u51fa\u73b0\u4e0d\u540c\u7ea7\u522b\u7684ALT\u5347\u9ad8\u30023-4\u7ea7\u7684AST\u6216ALT\u5347\u9ad8\u5206\u522b\u53d1\u751f\u57282.5%\u548c2.8%\u7684\u60a3\u8005\u4e2d\uff1b\u7531\u4e8e4.5%\u7684\u60a3\u8005\u5728\u6cbb\u7597\u540e\u6ca1\u6709\u8fdb\u884c\u809d\u529f\u80fd\u68c0\u67e5\uff0c\u56e0\u6b64\u5176\u53d1\u751f\u7387\u53ef\u80fd\u88ab\u4f4e\u4f30\u3002<\/p>\n

5\u3001\u9ad8\u5c3f\u9178\u8840\u75c7\uff1a355\u540d\u63a5\u53d7\u6069\u66f2\u66ff\u5c3c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u4e2d\uff0c32\u540d\u60a3\u8005\uff089%\uff09\u51fa\u73b0\u9ad8\u5c3f\u9178\u8840\u75c7\uff0c\u5e76\u4f34\u6709\u75c7\u72b6\u548c\u5c3f\u9178\u6c34\u5e73\u5347\u9ad8\u3002<\/p>\n

6\u3001QT\u95f4\u671f\u5ef6\u957f\uff1a355\u540d\u60a3\u8005\u5728\u670d\u7528\u6069\u66f2\u66ff\u5c3c\u540e\uff0c3.1%\u7684\u60a3\u8005\u81f3\u5c11\u6709\u4e00\u6b21\u57fa\u7ebf\u540e\u5fc3\u7535\u56fe\u8bc4\u4f30\u7684QTcF\u95f4\u671f\u5ef6\u957f>60ms\uff0c0.6%\u7684\u60a3\u8005\u51fa\u73b0QTcF\u95f4\u671f>500ms\u3002<\/p>\n

7\u3001\u89c6\u529b\u969c\u788d\uff1a\u6069\u66f2\u66ff\u5c3c\u4e34\u5e8a\u8bd5\u9a8c\u7684355\u540d\u60a3\u8005\u4e2d\uff0c21%\u7684\u60a3\u8005\u51fa\u73b0\u89c6\u529b\u53d8\u5316\uff0c\u5305\u62ec1\u7ea7\uff0882%\uff09\u30012\u7ea7\uff0814%\uff09\u548c3\u7ea7\uff080.8%\uff09\u3002<\/p>\n

8\u3001\u80da\u80ce\u6bd2\u6027\uff1a\u57fa\u4e8e\u4eba\u7c7b\u5148\u5929\u6027\u7a81\u53d8\u5bfc\u81f4TRK\u4fe1\u53f7\u6539\u53d8\u7684\u6587\u732e\u62a5\u9053\u3001\u52a8\u7269\u8bd5\u9a8c\u7684\u53d1\u73b0\u4ee5\u53ca\u5176\u4f5c\u7528\u673a\u5236\uff0c\u5b55\u5987\u670d\u7528\u6069\u66f2\u66ff\u5c3c\u65f6\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\u3002<\/p>\n

 <\/p>\n

\u3010<\/strong>\u4f5c\u7528\u673a\u5236<\/strong>\u3011<\/strong><\/p>\n

\u6069\u66f2\u66ff\u5c3c\u662f\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08TRK\uff09TRKA\u3001TRKB\u548cTRKC\uff08\u5206\u522b\u7531\u795e\u7ecf\u8425\u517b\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176[NTRK]\u57fa\u56e0NTRK1\u3001NTRK2\u548cNTRK3\u7f16\u7801\uff09\u3001\u539f\u764c\u57fa\u56e0\u916a\u6c28\u9178\u86cb\u767d\u6fc0\u9176ROS1\uff08ROS1\uff09\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u7684\u6291\u5236\u5242\uff0cIC50\u503c\u4e3a0.1\u81f32nM\u3002\u6069\u66f2\u66ff\u5c3c\u8fd8\u6291\u5236JAK2\u548cTNK2\uff0cIC50\u503c>5 nM\u7684\u3002\u6069\u66f2\u66ff\u5c3c\u7684\u4e3b\u8981\u6d3b\u6027\u4ee3\u8c22\u7269M5\u5bf9TRK\u3001ROS1\u548cALK\u7684\u4f53\u5916\u6d3b\u6027\u76f8\u4f3c\u3002<\/p>\n

 <\/p>\n

\u3010<\/strong>\u5b89\u5168\u4e0e\u7597\u6548<\/strong>\u3011<\/strong><\/p>\n

1\u3001ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/p>\n

\u6069\u66f2\u66ff\u5c3c\u7684\u7597\u6548\u5728ROS1\u9633\u6027\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u5408\u5e76\u4e9a\u7ec4\u4e2d\u8fdb\u884c\u8bc4\u4f30\uff0c\u8fd9\u4e9b\u60a3\u8005\u63a5\u53d7\u4e0d\u540c\u5242\u91cf\u548c\u8ba1\u5212\u7684\u6069\u66f2\u66ff\u5c3c\uff0890%\u6bcf\u5929\u53e3\u670d\u4e00\u6b21600 mg\uff09\uff0c\u5e76\u88ab\u7eb3\u5165\u4e09\u4e2a\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u3001\u975e\u76f2\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\uff1aALKA\uff0cSTARTRK-1\uff08NCT02097810\uff09\u548cSTARTRK-2\uff08NCT02568267\uff09\u3002<\/p>\n

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2\u3001NTRK\u57fa\u56e0\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624<\/p>\n

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