\u5e03\u52a0\u66ff\u5c3c\u8bf4\u660e\u4e66<\/p>\n
\u5546\u54c1\u540d\u79f0\uff1aBrigatinb<\/p>\n
\u751f\u4ea7\u5546\uff1a\u8054\u5408\u5236\u836f Alliance<\/p>\n
\u4e2d\u6587\u540d\u79f0\uff1a\u5e03\u52a0\u66ff\u5c3c<\/p>\n
\u82f1\u6587\u540d\u79f0\uff1aBrigatinib<\/p>\n
\u836f\u54c1\u6279\u6587\uff1a03 L 0954\/23<\/p>\n
\u3010\u6982\u62ec\u3011<\/p>\n
Brigatinib\u5c5e\u4e8e\u7b2c\u4e8c\u4ee3ALK\u6807\u9776\u6cbb\u7597\u836f\u7269\uff0c\u662f\u76ee\u524d\u7b2c\u4e00\u4e2a\u5bf9\u4e8ecrizotinib\u6cbb\u7597\u6709\u6297\u836f\u6027\u60a3\u8005\uff0c\u5176\u6cbb\u7597\u540e\u7684\u65e0\u75be\u75c5\u6076\u5316\u751f\u5b58\u65f6\u95f4(PFS)\u53ef\u4ee5\u8d85\u8fc7\u4e00\u5e74\u7684\u836f\u7269\u3002\u5bf9\u4e8e\u5305\u542b\u6709\u63a5\u53d7\u8fc7crizotinib\u6cbb\u7597\u4ee5\u53ca\u672a\u7ecfALK\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\uff0cBrigatinib\u7684\u603b\u4f53\u6709\u6548\u7387\u4e5f\u9ad8\u8fbe73%\u3002<\/p>\n
\u3010\u9002\u5e94\u75c7\u3011<\/p>\n
\u5e03\u52a0\u66ff\u5c3c\u662f\u4e00\u79cd\u6fc0\u9176\u6291\u5236\u5242\u9002\u7528\u4e3a\u6709\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)-\u9633\u6027\u8f6c\u79fb\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u4e14\u5bf9\u7528\u514b\u5511\u66ff\u5c3c[crizotinib]\u5df2\u8fdb\u5c55\u6216\u662f\u4e0d\u80fd\u8010\u53d7\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n
\u3010\u89c4\u683c\u3011<\/p>\n
90mg\/\u7247\uff0c30\u7247\/\u74f6\u3002<\/p>\n
\u3010\u8d2e\u5b58\u3011<\/p>\n
\u8d2e\u5b58\u4e8e20\u00b0C\u00a0\uff5e25\u00b0C (68\u00b0C\u00a0\uff5e77\u00b0F)\uff1b\u5141\u8bb8\u8303\u56f4\u4e3a15\uff5e30\u00b0C (59\u201386\u00b0F)\u6e29\u5ea6\u6761\u4ef6\u4e0b\u77ed\u9014\u8fd0\u8f93\u3002<\/p>\n
\u3010\u00a0\u7528\u6cd5\u7528\u91cf\u3011<\/p>\n
\u524d7\u5929\u6bcf\u5929\u4e00\u6b21\u53e3\u670d90mg\uff1b<\/p>\n
\u5982\u679c\u5728\u524d7\u5929\u5185\u8010\u53d790mg\uff0c\u5219\u5c06\u5242\u91cf\u589e\u52a0\u81f3180mg \u6bcf\u5929\u53e3\u670d\u4e00\u6b21\u3002<\/p>\n
\u3010\u00a0\u4e0d\u826f\u53cd\u5e94\u3011<\/p>\n
\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94(\u226525%)\u4e3a\u6076\u5fc3\uff0c\u8179\u6cfb\uff0c\u75b2\u4e4f\uff0c\u54b3\u55fd\uff0c\u548c\u5934\u75db\u3002<\/p>\n
\u3010\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879\u3011<\/p>\n
1.\u95f4\u8d28\u6027\u80ba\u75c5(ILD)\/\u80ba\u708e\uff1a\u5728\u63a8\u8350\u5242\u91cf\u65f6\u53d1\u751f\u57289.1%\u7684\u60a3\u8005\u3002\u76d1\u89c6\u5bf9\u65b0\u6216\u53d8\u574f\u7684\u547c\u5438\u75c7\u72b6\uff0c\u5c24\u5176\u662f\u5728\u6cbb\u7597\u7684\u7b2c\u4e00\u5468\u3002\u5bf9\u65b0\u6216\u53d8\u574f\u7684\u547c\u5438\u75c7\u72b6\u4e0d\u7ed9\u5e03\u5409\u4ed6\u6ee8\u548c\u53ca\u65f6\u5bf9ILD\/\u80ba\u708e\u8bc4\u4ef7\u3002\u6062\u590d\u65f6\uff0c\u6216\u51cf\u4f4e\u5242\u91cf\u6216\u6c38\u4e45\u5730\u7ec8\u6b62\u5e03\u52a0\u66ff\u5c3c\u3002<\/p>\n
2.\u9ad8\u8840\u538b\uff1a\u6cbb\u7597\u671f\u95f4\u76d1\u89c6\u8840\u538b2\u5468\u540e\u548c\u7136\u540e\u81f3\u5c11\u6bcf\u6708\u3002\u5bf9\u4e25\u91cd\u9ad8\u8840\u538b\uff0c\u4e0d\u7ed9\u5e03\u52a0\u66ff\u5c3c\uff0c\u7136\u540e\u5242\u91cf\u51cf\u4f4e\u6216\u6c38\u4e45\u5730\u7ec8\u6b62\u3002<\/p>\n
3.\u5fc3\u52a8\u8fc7\u7f13\uff1a\u6cbb\u7597\u671f\u95f4\u6709\u89c4\u5f8b\u5730\u76d1\u89c6\u5fc3\u7387\u548c\u8840\u538b\u3002\u5982\u75c7\u72b6\u6027\uff0c\u4e0d\u7ed9\u5e03\u52a0\u66ff\u5c3c\uff0c\u7136\u540e\u5242\u91cf\u51cf\u4f4e\u6216\u6c38\u4e45\u5730\u7ec8\u6b62\u3002<\/p>\n
4.\u89c6\u529b\u969c\u788d\uff1a\u5efa\u8bae\u60a3\u8005\u62a5\u544a\u89c6\u529b\u75c7\u72b6\u3002\u4e0d\u7ed9\u5e03\u52a0\u66ff\u5c3c\u548c\u5f97\u5230\u773c\u79d1\u8bc4\u4ef7\uff0c\u7136\u540e\u51cf\u4f4e\u5242\u91cf\u6216\u6c38\u4e45\u5730\u7ec8\u6b62\u5e03\u5409\u4ed6\u6ee8<\/p>\n
5.\u808c\u9178\u78f7\u9178\u6fc0\u9176(CPK)\u5347\u9ad8\uff1a\u6cbb\u7597\u671f\u95f4\u6709\u89c4\u5f8b\u5730\u76d1\u89c6CPK\u6c34\u5e73\u3002\u6839\u636e\u4e25\u91cd\u7a0b\u5ea6\uff0c\u4e0d\u7ed9\u5e03\u52a0\u66ff\u5c3c\uff0c\u7136\u540e\u6062\u590d\u6216\u51cf\u4f4e\u5242\u91cf\u3002<\/p>\n
6.\u80f0\u9176\u5347\u9ad8\uff1a\u6cbb\u7597\u671f\u95f4\u6709\u89c4\u5f8b\u5730\u76d1\u89c6\u8102\u80aa\u9176\u548c\u6dc0\u7c89\u9176\u6c34\u5e73\u3002\u6839\u636e\u4e25\u91cd\u7a0b\u5ea6\uff0c\u4e0d\u7ed9\u5e03\u52a0\u66ff\u5c3c\uff0c\u7136\u540e\u6062\u590d\u6216\u51cf\u4f4e\u5242\u91cf\u3002<\/p>\n
7.\u9ad8\u8840\u7cd6\uff1a\u5e03\u5409\u4ed6\u6ee8\u5f00\u59cb\u524d\u548c\u6cbb\u7597\u671f\u95f4\u5e38\u89c4\u5730\u8bc4\u4f30\u7a7a\u8179\u8840\u6e05\u8461\u8404\u7cd6\u3002\u5982\u4e0d\u80fd\u7528\u6700\u4f18\u836f\u7269\u5904\u7406\u63a7\u5236\uff0c\u4e0d\u7ed9\u5e03\u52a0\u66ff\u5c3c\uff0c\u7136\u540e\uff0c\u6839\u636e\u4e25\u91cd\u7a0b\u5ea6\u8003\u8651\u5242\u91cf\u51cf\u4f4e\u6216\u6c38\u4e45\u5730\u7ec8\u6b62\u3002<\/p>\n
8.\u80da\u80ce\u80ce\u513f\u6bd2\u6027\uff1a\u53ef\u80fd\u81f4\u80ce\u513f\u5371\u5bb3\u3002 \u5fe0\u544a\u6709\u751f\u6b96\u6f5c\u80fd\u5973\u6027\u5bf9\u80ce\u513f\u6f5c\u5728\u98ce\u9669\u3002\u548c\u4f7f\u7528\u975e\u6fc0\u7d20\u6709\u6548\u907f\u5b55\u65b9\u6cd5\u3002<\/p>\n
\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/p>\n
CYP3A\u6291\u5236\u5242\uff1a\u907f\u514d\u5e03\u52a0\u66ff\u5c3c\u4e0e\u5f3aCYP3A\u6291\u5236\u5242\u7684\u540c\u65f6\u4f7f\u7528\u3002\u5982\u4e00\u79cd\u5f3aCYP3A\u6291\u5236\u5242\u7684\u540c\u65f6\u4f7f\u7528\u662f\u4e0d\u80fd\u907f\u514d\u3002\u51cf\u4f4e\u5e03\u52a0\u66ff\u5c3c\u7684\u5242\u91cf\u3002<\/p>\n
CYP3A\u8bf1\u5bfc\u5242\uff1a\u907f\u514d\u5e03\u52a0\u66ff\u5c3c\u4e0e\u5f3aCYP3A \u8bf1\u5bfc\u5242\u7684\u540c\u65f6\u4f7f\u7528\u3002<\/p>\n
CYP3A\u5e95\u7269\uff1a\u6fc0\u7d20\u907f\u5b55\u836f\u53ef\u80fd\u662f\u65e0\u6548\u7531\u4e8e\u51cf\u4f4e\u66b4\u9732\u3002<\/p>\n
\u3010\u7279\u6b8a\u4eba\u7fa4\u3011<\/p>\n
\u54fa\u4e73\uff1a\u5efa\u8bae\u4e0d\u54fa\u4e73\u5582\u517b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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